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A multicenter study for the detection and the development of nationwide reporting system of toxic liver injury

Hallym University
Dong Joon Kim


ABSTRACT - A hundred ten toxic liver injury cases were newly detected from May to October 2005 in 17 university hospitals. Blood samples was collected from 108 cases of reported for SNP study. Etiologies of enrolled cases included herb medicine(33.6%), conventional drugs(28.2%), health food(11.8%), folk remedy(5.5%) and others(20.0%) in order. The most common seller or prescribing person of causative food or drugs was a herbalist(28.2%). The frequency of hepatitis type, mixed type, and cholestatic type according to R value were 95 cases (86.4%), 12 cases (10.9%), and 3 cases (2.7%), respectively. The mean RUCAM score was 7.0¡¾1.7. Nine cases(8.2%) were proven to be absolute, 68 cases(61.8%) were scored to be probable. On the other hand, another multi-center study was performed to develop investigating method of medical cost for health in Korean. This study revealed that total medical cost associated with health in each Korean patient(including conventional medicine, Oriental medicine, health food, etc) was 502 thousands won. The expenditure of patients who used oriental medicine to it was 420 thousands won.

1) The most frequent etiology of toxic liver injury was herb medicine(33.6%). Other etiologies of toxic liver injuries were conventional drugs, health food, and folk remedy in order of importance.
2) Most of toxic liver injury was classified as hepatitis type.
3) Total medical cost associated with health in each patient was 502 thousands won, and herb medicine played an important role with this.
4) We have tried to collect the data of SNP about gene associated with hepatotoxicity and to get basic technique. Having basic technology producing DNA chips for screening of SNP, SNP patterns are in investigating and it is expected to find new specific SNP markers in Korean patients with toxic liver injury.

Key words : Hepatotoxicity, Toxic Liver Injury, Herb medicine, Medical Cost, Single Nucleotide Polymorphism

*Corresponding author General Toxicology Team Young Na £º Yum(Tel. 02/380/1817)

* Ãâó ; ½ÄǰÀǾàǰ¾ÈÀüû¿¬±¸º¸°í¼­ Á¦9±Ç The Annual Report of KFDA, Vol.9. 728-729. 2005

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